前言

利用燕趙分子生(sheng)物(wu)學會化(hua)解病(bing)(bing)學協會理事消化(hua)道發動機學組發布消息的(de)《中萎(wei)縮(suo)性(xing)型嚴(yan)(yan)(yan)重(zhong)(zhong)出(chu)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)腹瀉(xie)(xie)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)專家教授精準醫學意見和建議(2019)》體現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian) ，各國(guo)(guo)長大萎(wei)縮(suo)性(xing)型嚴(yan)(yan)(yan)重(zhong)(zhong)出(chu)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)腹瀉(xie)(xie)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)的(de)起病(bing)(bing)比(bi)率(lv)為(wei)4.0%~10.0%，山(shan)東省約有(you)五千(qian)萬(wan)18歲(sui)人目前在備受嚴(yan)(yan)(yan)重(zhong)(zhong)出(chu)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)腹瀉(xie)(xie)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)的(de)擔憂。伴隨年領(ling)上漲，嚴(yan)(yan)(yan)重(zhong)(zhong)出(chu)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)腹瀉(xie)(xie)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)的(de)起病(bing)(bing)率(lv)迅速提(ti)高。老齡(ling)人年齡(ling)段中萎(wei)縮(suo)性(xing)型嚴(yan)(yan)(yan)重(zhong)(zhong)出(chu)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)腹瀉(xie)(xie)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)的(de)起病(bing)(bing)率(lv)回升至50%，而6六歲(sui)不(bu)低于年齡(ling)段的(de)萎(wei)縮(suo)性(xing)型嚴(yan)(yan)(yan)重(zhong)(zhong)出(chu)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)腹瀉(xie)(xie)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)起病(bing)(bing)率(lv)亦是高達(da)獨角獸67%不(bu)低于。另(ling)有(you)統計數據體現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian) ，七十(shi)歲(sui)不(bu)低于年齡(ling)段萎(wei)縮(suo)性(xing)型嚴(yan)(yan)(yan)重(zhong)(zhong)出(chu)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)腹瀉(xie)(xie)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)的(de)起病(bing)(bing)率(lv)達(da)23.0%，80歲(sui)不(bu)低于可以達(da)到(dao)38.0%。各國(guo)(guo)嚴(yan)(yan)(yan)重(zhong)(zhong)出(chu)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)腹瀉(xie)(xie)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)現(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)(xian)象(xiang)(xiang)(xiang)(xiang)狀況絕(jue)不(bu)容強毒。

研究摘要

[1]本設(she)計(ji)所采用(yong)了微康復合益生菌(jun)菌(jun)株初凝魏茨(ci)曼氏(shi)菌(jun)BC99，設(she)計(ji)了其對慢(man)性病大(da)便(bian)干結朋(peng)友不適反應可以改善的(de)情(qing)況及胃腸菌(jun)群的(de)導致。

[2]本科學(xue)研究(jiu)方案共收錄103名受試(shi)者，自由分類勸解劑(ji)組和(he)BC99調(diao)控(kong)組，BC99調(diao)控(kong)含量(liang)為20億CFU/天，調(diao)控(kong)4周后(hou)，評價提(ti)高(gao)排(pai)泄時間(jian)，排(pai)泄物(wu)物(wu)理性質，用16S rRNAmtk量(liang)測序科技科學(xue)研究(jiu)方案可以使腸(chang)胃枯草芽孢桿菌(jun)制(zhi)品的變幻。

相關專利、臨床試驗結論

1.BC99加入女性拉大便時長

圖1 BC99指導的(de)排宿便(bian)多少(shao)次波動

由圖1得知，與關心的話的話劑組相對比，調理4周后，初凝魏茨曼氏菌BC99組，人群參與小便機會差異性增強；與基線數據資料相對比，兩對大概一天參與小便機會均有了增強，但BC99組人群大概一天參與小便機會差異性超過關心的話的話劑組，意味著BC99能差異性增強人群小便機會，改善效果人群嚴重便秘病癥。

2.BC99可改(gai)善效果患有糞水(shui)特性

圖2 兩個患有糞水(shui)的Bristol得分對比

由圖(tu)2可(ke)看得(de)出，在用到BC99糾(jiu)正4周(zhou)后(hou)，人(ren)群(qun)屎尿物理(li)性質正相關影(ying)響，該結果顯示說明(ming)怎么寫BC99能正相關優化成年人(ren)群(qun)拉(la)大(da)便稠狀度。

3.BC99可可以改善排便不暢臨(lin)床癥狀

圖(tu)3 愛美者(zhe)性生(sheng)活產(chan)品估評打分(fen)與腹(fu)瀉征兆估評打分(fen)的相比(bi)

由圖3可見，在利用BC99診治4周后，病愛(ai)美(mei)者過(guo)日子質評判標(biao)準排便(bian)不暢(chang)臨(lin)床表現評判標(biao)準都同質性升高，說BC99能能升高病愛(ai)美(mei)者過(guo)日子質，持續改善排便(bian)不暢(chang)臨(lin)床表現。

4.BC99有無效可以調節患有胃腸菌群

圖4 調控后一(yi)組患(huan)兒腸腔菌群區別(bie)

由圖4見到(dao)，經BC99預防后(hou)，人(ren)群(qun)腸(chang)管(guan)菌群(qun)改變，擬桿(gan)菌屬，雙歧桿(gan)菌屬等的相應(ying)豐度與(yu)大便每一(yi)次(ci)呈(cheng)正相關內容，證(zheng)明BC99能夠有郊轉換人(ren)群(qun)腸(chang)管(guan)菌群(qun)，因素(su)做(zuo)用(yong)體制會在拆遷(qian)中遇到(dao)到(dao)對腸(chang)管(guan)菌類(lei)（有點(dian)是(shi)雙歧桿(gan)菌）的轉換，并且(qie)對谷胱甘肽代謝轉化渠道影響(xiang)到(dao)，其在慢性炎癥生(sheng)理(li)反應(ying)中起主要做(zuo)用(yong)。

匯報

在本研究分(fen)析中(zhong)(zhong)，自己對急漫性長(chang)(chang)期(qi)便(bian)(bian)秘癥(zheng)(zheng)狀現(xian)象的(de)(de)初中(zhong)(zhong)生(sheng)實(shi)施期(qi)限4周(zhou)的(de)(de)BC99雙(shuang)歧桿菌(jun)調查耐壓，結(jie)果顯示表面，BC99更有效果驅動(dong)蠕動(dong)消化(hua)，能同質(zhi)性優化(hua)大便(bian)(bian)不成形黏稠度，緩減長(chang)(chang)期(qi)便(bian)(bian)秘癥(zheng)(zheng)狀現(xian)象優化(hua)提(ti)供(gong)的(de)(de)初期(qi)癥(zheng)(zheng)狀，提(ti)供(gong)提(ti)供(gong)的(de)(de)工(gong)作服務質(zhi)量，控制核心(xin)的(de)(de)胃腸(chang)胃微海洋(yang)生(sheng)物工(gong)程(cheng)群(qun)，如雙(shuang)歧桿菌(jun)和瘤胃球(qiu)菌(jun)，這部分(fen)微海洋(yang)生(sheng)物工(gong)程(cheng)群(qun)與谷胱甘肽排泄等核心(xin)排泄經過(guo)關(guan)以。便(bian)(bian)是，BC99被聲明(ming)是種更有效果、安全(quan)性高的(de)(de)治療方法的(de)(de)選擇(ze)，可(ke)緩減初中(zhong)(zhong)生(sheng)急漫性長(chang)(chang)期(qi)便(bian)(bian)秘癥(zheng)(zheng)狀現(xian)象，提(ti)升胃腸(chang)胃菌(jun)群(qun)平橫，影向核心(xin)排泄經過(guo)。